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    Aedes: Entomology study design
    Aedes: Epidemiology study design

    Accurately evaluating the effectiveness and efficacy of both current and new vector control tools and approaches is crucial for monitoring and reducing the risk and burden of vector-borne disease in endemic settings. Demonstrating the current, and predicting future, impact of current tools in any setting  should be carried out through an assessment of both the vector and human populations within specific locations, taking into account both local conditions, structures, and practices related to disease control. For the introduction of new vector control tools and strategies, the WHO recommends that products are trialled under Phase III conditions with clear epidemiological endpoints before they can enter phase VI trials under ‘real world’ operational conditions.

    This section provides guidance and toolkits for planning, designing, and implementing both entomological and epidemiological research to measure and document the effectiveness, and efficacy of different vector control tools within different environments/conditions. 

    WHO Guidance for Phase III Vector Control Efficacy Trials
    Download PDF
    Improving Quality of Vector Control Trials
    Download PDF
    Entomology Research Trial Design: Further Resources
    Visit website
    Plant extracts for developing mosquito larvicides: From laboratory to the field, with insights on the modes of action
    Visit website
    WHO Guidance on Epidemiological Trials for Vector Control Products
    Download PDF
    Selecting Study Design Methods for MMP Groups
    Download PDF
    Guidance framework for testing genetically modified mosquitoes, second edition
    Download PDF
    An Expert Review of Spatial Repellents for Mosquito Control
    Visit website
    Aedes: Entomology study design

    Accurately evaluating the effectiveness and efficacy of both current and new vector control tools and approaches is crucial for monitoring and reducing the risk and burden of vector-borne disease in endemic settings. Demonstrating the current, and predicting future, impact of current tools in any setting  should be carried out through an assessment of both the vector and human populations within specific locations, taking into account both local conditions, structures, and practices related to disease control. For the introduction of new vector control tools and strategies, the WHO recommends that products are trialled under Phase III conditions with clear epidemiological endpoints before they can enter phase VI trials under ‘real world’ operational conditions.

    This section provides guidance and toolkits for planning, designing, and implementing both entomological and epidemiological research to measure and document the effectiveness, and efficacy of different vector control tools within different environments/conditions. 

    WHO Guidance for Phase III Vector Control Efficacy Trials
    Download PDF
    Improving Quality of Vector Control Trials
    Download PDF
    Entomology Research Trial Design: Further Resources
    Visit website
    Plant extracts for developing mosquito larvicides: From laboratory to the field, with insights on the modes of action
    Visit website
    Aedes: Epidemiology study design
    WHO Guidance on Epidemiological Trials for Vector Control Products
    Download PDF
    Selecting Study Design Methods for MMP Groups
    Download PDF
    Guidance framework for testing genetically modified mosquitoes, second edition
    Download PDF
    An Expert Review of Spatial Repellents for Mosquito Control
    Visit website