Never heard of this, but it sounds interesting and I thought you may want to be aware this new product. Here is the title, and then the Abstract follows after: Singh S, Govekar A, Mazumdar D, Dhimmar A, Sahastrabudhe H, Gajjar A, Kumar P, Tothadi S, Dodiya PJ, Shinde UP, Mohanty AK. Glaucarubinone from Simarouba glauca DC. as a potential biocontrol agent for mosquito vector management. Natural Product Research. 2024 Jun 21:1-8…..and here is the Abstract: The study explored Simarouba glauca DC. for mosquito larvicidal potential by performing bioactivity-guided chemical investigation of its root extract resulting in isolation of the known bioactive metabolite glaucarubinone (1). Mosquito larvicidal activity of glaucarubinone (1) against the three vector species viz. Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus was determined using a modified WHO 2005 protocol. It was observed that Culex quinquefasciatus larvae were the most susceptible species with LC50 13.88 ppm and LC90 70.01 ppm followed by Aedes aegypti and Anopheles stephensi at 24 h of exposure. The mode of action as observed microscopically is the lysis of midgut and thorax cells of the third instar larvae. The crystal structure of the glaucarubinone (1) is reported for the first time using X-ray crystallography. This phytochemical product has the potential to act as a green alternative to existing chemical-based insecticides for integrated vector management.